In the United States, she has appeared on the podiums of many orchestras including the National Symphony Orchestra, the American Symphony, and the symphonies of Houston, Phoenix, San Diego, Honolulu, Sacramento, Tucson, Denver, St. Paul, Toledo, Charleston, Columbus, and Indianapolis, in addition to the Buffalo and Rochester philharmonic orchestras, and the Louisville and Florida orchestras.

Foreign engagements have taken her to Germany, Spain, China, Italy, Portugal, Belgium, Mexico, Canada and Austria, often as the first woman to occupy the orchestras' podiums. In future seasons she will be guest conducting in San Jose and Chaperon, South Africa, as well as returning to the English Chamber Orchestra, the Mannheim Orchestra, Czech Philharmonic of Bruno, and Orquestra Sinfonica Del Principado de Asturias in Spain. Summer assignments have found her at the Aspen, Tanglewood, Cabrillo, OK Mozart International, Peter Britt, and Music in the Mountain festivals.

Maestro Falletta is the winner of many of the world's most prestigious conducting prizes, including the Stokowski, Toscanini, and Bruno Walter awards. Her recordings with the London Symphony Orchestra and the Women's Philharmonic have been named "Best Classical Recording" by the National Association of Independent Record Producers and given the "Most Creative Programming" award from ASCAP for creative programming, as well as the American Symphony Orchestra League's prized John S Edwards Award for programming. Not only has Maestro Falletta an extensive repertoire of over 1,100 works performed in concert, but she also has been a consistent champion of new music. Sixty world premieres have been featured among the almost three hundred works by American composers that she has performed.